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Chymase level in dengue virus infection with or without positive Non-Structural 1(NS1)

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Pages 41 - 46
Received : 29 April 2019
Accepted : 13 April 2020
Published : 30 December 2019


Thrombocytopenia, leukopenia, and monocytosis are laboratory parameters in the diagnosis of dengue virus infection. In addition to monocyte cells, mast cells also play a role in the innate immune response, where degranulation of mast cells will occur, which will secretion the active vaso mediator, Chymase. Chymase has a role in increasing vascular permeability resulting in plasma leakage in patients with dengue virus infection to determine the number of platelets, leukocytes, monocytes and chymase levels in patients with dengue infection in the acute phase. The platelet count mean in NS1 (+) was 132,140 cells / mm3 and the platelet count in the NS1 group was (-) 176,000 cells / mm3. The mean leukocytes NS1 (+) showed results of 4,350 cells / mm3 and NS1 (-) 5,250 cells / mm3. The mean monocyte NS1 (+) monocyte count was 8.26%, and NS1 (-) group was 8.76%. There were no significant differences in platelet counts, leukocytes and monocytes between NS1 (+) and NS1 (-) (P value> 0.05). The mean Chymase NS1 (+) 23.48, NS1 (-) 23.05 ng / mL and the control group 1.47ng / mL.

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1. Kementrian, Kesehatan RI. infodatin Demam Berdarah Dengue di Indonesia 2016.pdf. 2016.
2. Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Publ Gr. 2016;2:1-26. doi:10.1038/nrdp.2016.55
3. Yap SSL, Nguyen-khuong T, Rudd PM, Alonso S. Dengue Virus Glycosylation : What Do We Know ? 2017;8(July):1-16. doi:10.3389/fmicb.2017.01415
4. Perng GC, Yoksan S, Pattanapanyasat K, Ahmed R, Pulendran B. Dengue Virus Infection Induces Expansion of a CD14+ CD16+ Monocyte Population that Stimulates Plasmablast Differentiation. 2015;16(1):115-127. doi:10.1016/j.chom.2014.06.001.Dengue
5. John ALS. Influence of Mast Cells on Dengue Protective Immunity and Immune Pathology. 2013;9(12):2011-2014. doi:10.1371/journal.ppat.1003783
6. Sala-cunill A. The Mast Cell, Contact , and Coagulation System Connection in Anaphylaxis. 2017;8(July):1-6. doi:10.3389/fimmu.2017.00846
7. Tissera H, Rathore APS, Leong Y, et al. Chymase Level Is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients. 2018;216(April). doi:10.1093/infdis/jix447
8. Pejler G, Ro E, Waern I, Wernersson S. Review article Mast cell proteases : multifaceted regulators of inflammatory disease. 2018;115(24):4981-4991. doi:10.1182/blood-2010-01-257287.
9. Wernersson S, Pejler G. Mast cell secretory granules : armed for battle. Nat Publ Gr. 2014;(June). doi:10.1038/nri3690
10. Badave GK, Swaroop PS, Rao PN. Original Research Article Importance of NS1 antigen detection and its association with platelet count for early diagnosis of dengue virus infection. 2015;4(3):779-784.
11. Siregar D, Djadja IM, Arminsih R. Analysis of the Risk Factors of Dengue Hemorrhagic Fever ( DHF ) In Rural Populations in Panongan Subdistrict , Tangerang 2016. 2017;2017:119-128. doi:10.18502/kls.v4i1.1373
12. Joshi AA, Gayathri BR, Muneer F. Dynamics of differential count in dengue. 2018;5(1):145-150.
13. Jatmiko SW. Korelasi umur dengan kadar hematokrit, jumlah leukosit, dan trombosit pasien infeksi virus dengue. 2018;10:126.
14. Utari FP, Efrida, Kadri H. Perbandingan Nilai Hematokrit dan Jumlah Trombosit antara Infeksi Dengue Primer dan Dengue Sekunder pada Anak di RSUP Dr. M. Djamil. 2018;7(1):118-123.
15. Tsai J, Chang J, Chang K, et al. Transient Monocytosis Subjugates Low Platelet Count in Adult Dengue Patients. 2017;457785. doi:10.1159/000457785
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How to Cite This

Kasiyati, M., Nugraha, J., & Kahar, H. (2019). Chymase level in dengue virus infection with or without positive Non-Structural 1(NS1). Jurnal Teknologi Laboratorium, 8(2), 41–46. https://doi.org/10.29238/teknolabjournal.v8i2.167

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