Total Lymfosit Count (TLC) with CD4 in HIV/AIDS Patients at Kupang
Human Immunodeficiency Virus (HIV) is a retrovirus originating from the retroviridae family of the genus lentivirus that infects and damages cells that have a molecule Cluster of Differentiation 4 (CD4), especially T lymphocytes that have receptors with high affinity for HIV. Total lymphocyte count / TLC has been proposed as an alternative guide to CD4 in limited health facilities. This study aims to determine the correlation between Total Lymphocyte Count (TLC) and CD4 in HIV/AIDS patients in the W.Z. Johannes Kupang hospital. The type of this research was observational analytic with a cross-sectional design. The study was conducted on 121 samples of patients who performed CD4 examination and Total Lymphocytic Count (TLC) in the laboratory of W.Z.Johannes Kupang Hospital. The Spearman correlation test shows a significance value of 0,000 with a Spearman correlation value of 0.799. Based on the results of this study it can be concluded that there is a significant correlation between Total Lymphocyte Count and CD4 and shows the direction of positive correlation with a very strong relationship, where the increase in the number of Total Lymphocyte Count is in line with the increase in CD4 counts.
There is no Figure or data content available for this article
2. Kementerian Kesehatan RI. Laporan Situasi Perkembangan HIV/AIDS Dan PIMS Di Indonesia Tahun 2018. Jakarta; 2018. doi:10.1017/CBO9781107415324.004.
3. Rostina R, Aprianti S, Arif M. Prediksi Jumlah Sel Limfosit T Cd4+ Menggunakan Nilai Tlc (Total Lymphocyte Count) Pada Penderita Hiv/Aids. Indones J Clin Pathol Med Lab. 2018;14(2):64.
4. Kambuno, N., Sari, A., Nurdin, K., Novicadlitha, Y., & Siregar I. The relation of blood donorsâ€™ characteristic toward prevalences of HBsAg and Anti-HCV on blood transfussion unit of PMI in Province of East Nusa Tenggara. In: Waangsir F, Kase S, eds. Proceeding 1st. International Conference Health Polytechnic of Kupang. Kupang, East Nusa Tenggara: Health Polytechnic of Kupang; 2018:303-310.
5. Kwantwi LB, Tunu BK, Boateng D, Quansah DY. Body Mass Index, Haemoglobin, and Total Lymphocyte Count as a Surrogate for CD4 Count in Resource Limited Settings. J Biomarkers. 2017;2017:1-6. doi:10.1155/2017/7907352.
6. Anto EO, Obirikorang C, Acheampong E, et al. Evaluation of individual and combined markers of urine dipstick parameters and total lymphocyte count as a substitute for CD4 count in low-resource communities in Ghana. Dis Markers. 2018;2018. doi:10.1155/2018/7485942.
7. Widiyanti M, Hutapea H. Hubungan Jumlah Cluster of Differentiation 4 (CD4) dengan Infeksi Oportunistik Pada Pasien HIV/AIDS di Rumah Sakit Umum Daerah (RSUD) DOK II Jayapura. J Biol Papua. 2016;7(1):16-21.
8. Fransiska YY, Kurniawaty E. Anemia pada Infeksi HIV. J Major. 2015;4(9):123-128.
9. Karanth S, Rau N, Shanbhogue V, Pruthvi B, Gupta A, Kamath A. Utility of total lymphocyte count as a surrogate for absolute CD4 count in the adult Indian HIV population: A prospective study. Avicenna J Med. 2014;4(1):1. doi:10.4103/2231-0770.127413.
10. Rafatpanah H, Essmailian L, Hedayati-Moghaddam MR, et al. Evaluation of non-viral surrogate markers as predictive indicators for monitoring progression of human immunodeficiency virus infection: An eight-year analysis in a regional center. Jpn J Infect Dis. 2016;69(1):39-44.
11. Gholamzadeh Baeis M, Amiri G, Miladinia M. The effects of setarud on the immunological status of HIV-positive patients: Efficacy of a novel multi-herbal drug. Avicenna J phytomedicine. 2017;7(3):232-241.
12. Astari L, Sawitri SY HD. Viral Load pada infeksi HIV. Berk Ilmu Kesehat Kulit Kelamin. 2009;21(1):31-39.
13. Chen J, Li W, Huang X, et al. Evaluating Total Lymphocyte Count as a Surrogate Marker for CD4 Cell Count in the Management of HIV-Infected Patients in Resource-Limited Settings: A Study from China. PLoS One. 2013;8(7):4-9. doi:10.1371/journal.pone.0069704
14. Greene E, Pack A, Stanton J, et al. â€œIt makes you Feel like someone caresâ€ acceptability of a financial incentive intervention for HIV viral suppression in the HPTN 065 (TLC-Plus) study. PLoS One. 2017;12(2):1-18. doi:10.1371/journal.pone.0170686.
15. I Made Wikrama Resindra, Ilsa Hunaifi, I Gede Yasa Asmara. Korelasi antara Jumlah Limfosit Total dan Limfosit Cd4+ pada Pasien HIV/AIDS di RSUD Provinsi NTB. Unram Med J. 2019;8(2):24. doi:10.29303/jku.v8i2.339.
16. Sanjaya A, Sugiarto C, Jonathan R. Correlation of Total Lymphocyte Count with CD4 Count in HIV/AIDS Patients. J Med Heal. 2015;1(1):0-7. doi:10.28932/jmh.v1i1.500.
17. Akinola NO, Olasode O, Adediran IA, et al. The Search for a Predictor of CD4 Cell Count Continues: Total Lymphocyte Count Is Not a Substitute for CD4 Cell Count in the Management of HIV-Infected Individuals in a Resource-Limited Setting. Clin Infect Dis. 2004;39(4):579-581.
18. Irianto HP. Jumlah limfosit sebelum dan sesudah terapi antiretroviral dan korelasinya dengan jumlah sel cd4. 2016.
19. Aman AK, . T, . R. Pemeriksaan CD4 Hubungannya dengan Stadium Penyakit HIV. Indones J Clin Pathol Med Lab. 2018;14(3):93. doi:10.24293/ijcpml.v14i3.926.
20. Nyoko YO, Putra IWGAE, Sawitri AAS. Hubungan Karakteristik Demografi, Klinis dan Faktor Risiko Terinfeksi HIV dengan Koinfeksi HIV/TB di Klinik Amertha Yayasan Kerti Praja Denpasar. Public Heal Prev Med Arch. 2014;2(2):95.
21. Widiyanti M, Fitriana E, Iriani E. Karakteristik Pasien Koinfeksi Tb-Hiv Di Rumah Sakit Mitra Masyarakat Mimika Papua. Sel J Penelit Kesehat. 2017;3(2):49-55. doi:10.22435/sel.v3i2.6382.49-55.
22. Swity AF, Setiabudi D, Garna H. Korelasi Total Lymphocyte Count terhadap CD4 pada anak dengan Infeksi Human Immunodeficiency Virus. Sari Pediatr. 2016;15(2):81.
How to Cite This
Copyright and Permissions
Publishing your paper with Jurnal Teknologi Laboratorium (JTL) means that the author or authors retain the copyright in the paper. JTL granted an exclusive reuse license by the author(s), but the author(s) are able to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by JTL in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.
JTL journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially.
JTL journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:
- BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- SA: If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.