Absolute leukocytes count and NLR as a diagnostic and prognostic biomarkers for severity of COVID-19 infection

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Khalid Abdelsamea Mohamedahmed https://orcid.org/0000-0001-7084-6106 Adam Dawoud Abakar


The current COVID-19 pandemic challenges not only the lack of awareness of the disease, but also the rapid diagnosis, the prediction of severe early disease, the clinical characterization of mortality and severity of patients, and the effective management that affects the global scale, resulting in low capacities of healthcare systems, the resilience of systems and global economics. Therefore, early differential diagnosis and prediction of SARS-COV-2 infection severity are needed. CRP and NLR are diagnostic markers commonly used, most available, effective, and economically used primarily to evaluate the ongoing systemic inflammatory response.


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Mohamedahmed, K., & Abakar, A. (2021). Absolute leukocytes count and NLR as a diagnostic and prognostic biomarkers for severity of COVID-19 infection. Jurnal Teknologi Laboratorium, 10(1), 03-05. https://doi.org/https://doi.org/10.29238/teknolabjournal.v10i1.263


1. WHO. Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: interim guidance, 2 March 2020 [R]. Geneva: World Health Organization; 2020.
2. Wang P, Anderson N, Pan Y, et al. The SARS-CoV-2 outbreak: diagnosis, infection prevention, and public perception. Clin Chem. 2020; 66 (5):644–651. doi: 10.1093/clinchem/hvaa080.
3. Chen W, Zheng KI, Liu S, et al. Plasma CRP level is positively associated with the severity of COVID-19. Ann Clin Microbiol Antimicrob. 2020;19:18. doi: 10.1186/s12941-020-00362-2.
4. Tan C, Huang Y, Shi F, et al. C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early. J Med Virol. 2020;92:856-62. doi: 10.1002/jmv.25871.
5. Feng Z, Yu Q, Yao S, et al. Early prediction of disease progression in 2019 novel coronavirus pneumonia patients outside Wuhan with CT and clinical characteristics. BMJ. 2020; 36:8. doi.org/10.1101/2020.02.19.20025296.
6. Yufei Y, Mingli L, Xuejiao L, et al. Utility of the neutrophil-to-lymphocyte ratio and Creactive protein level for coronavirus disease 2019 (COVID-19). Scand J Clin Lab Invest. 2020;14:1-5. doi: 10.1080/00365513.2020.1803587.
7. He Z, Zhao C, Dong Q, et al. Effects of severe acute respiratory syndrome (SARS) coronavirus infection on peripheral blood lymphocytes and their subsets. Int J Infect Dis. 2005; 9: 323–30. doi: 10.1016/j.ijid.2004.07.014.
8. Forget P, Khalifa C, Defour JP, et al. What is the normal value of the neutrophil-to lymphocyte ratio? BMC Res Notes. 2017; 10: 12. doi: 10.1186/s13104-016-2335-5.
9. Khourssaji M, Chapelle V, Evenepoel A, et al. A biological profile for diagnosis and outcome of COVID-19 patients. Clin Chem Lab Med. 2020; 58(12): 2141-2150. doi: 10.1515/cclm-2020-0626 PMID: 33064667.
10. Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T. Biomarkers associated with COVID-19 disease progression, Critical Reviews in Clinical Laboratory Sciences. 2020; 57(6):389-399. doi: 10.1080/10408363.2020.1770685.