164
Abstract Views
52
PDF Download
Immunology

Assessing the Therapeutic Potential of Arctium lappa L. (Burdock Root) Ethanol Extract in Wound Healing on Male Rattus norvegicus

Imam Faizal Department of Applied Bachelor's Degree of Medical Laboratory Technology, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
,
Jodi Irmansa Department of Applied Bachelor's Degree of Medical Laboratory Technology, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
,
Ira Pangesti Department of Applied Bachelor's Degree of Medical Laboratory Technology, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
,
Frinsisca Oktaviany Department of Applied Bachelor's Degree of Medical Laboratory Technology, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
,
Aprillia Avivah Ledyana Mas’ud Department of Applied Bachelor's Degree of Medical Laboratory Technology, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
,
Dilla Putri Oktafiani Department of Applied Bachelor's Degree of Medical Laboratory Technology, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
,
Silviana Dwi Yuniasari Department of Bachelor of Pharmacy, Faculty of Pharmacy, Science, and Technology, University Al-Irsyad Cilacap, Cilacap, Indonesia, Indonesia Correspondence imamdfaizal@universitasalirsyad.ac.id
Pages 83-95
Browse this journal

Abstract

Burdock root (Arctium lappa L.) is a good plant for wound healing because it contains lignans, flavonoids, and phenolic acid which have the potential as anti-inflammatory, anti-allergic, anti-cancer, free radical scavengers and antioxidants. This research aims to determine the effectiveness of burdock root extract (Arctium lappa L.) on wound healing in white rats (Rattus norvegicus). The research design of laboratory experiments, with animal samples Rattus norvegicus, were grouped into five groups: three treatment groups with burdock root extract concentrations of 15%, 30%, and 45% and two control groups such positive control with povidone iodine and negative control with basic gel. The results showed that burdock root extract (Arctium lappa L.) concentrations of 30% and 45% had significant differences between the positive and negative control groups in the wound healing process. Burdock root extract (Arctium lappa L.) with a concentration of 45% has the best effectiveness compared to a concentration of 30% or 15% in the healing process of cuts in white rats (Rattus norvegicus).


 

There is no Figure or data content available for this article

References

  • Panjaitan J, Girsang E, Chiuman L, Indonesia UP. Effectiveness of temulawak (Curcuma xanthorrhiza) ointments as wound healing agents in wistar rats. 2022;11(November):95-104. doi:10.29238/teknolabjournal.v11i2.376
  • Shedoeva A, Leavesley D, Upton Z, Fan C. Wound Healing and the Use of Medicinal Plants. 2019;2019(Figure 1).
  • Samudra AG. Uji Efektivitas Ekstrak Etanol Daun Sawo (Manilkara Zapota L) Pada Luka Sayat Pada Kelinci Jantan (Oryctolagus cuniculus) Agung Giri Samudra, Fathnur Sani K, Dara Permata Sari Akademi Farmasi Al - Fatah Bengkulu. 2019;6(1).
  • Ruauw EF, Wantania FE, Leman MA. PENGARUH LIDAH BUAYA ( Aloe vera ) TERHADAP WAKTU PENUTUPAN LUKA SAYAT PADA MUKOSA RONGGA MULUT. 2016;5(2):22-28.
  • Ghorat F, Azizkhani MA, Najy S, Ranjbary AG, Doostishoar F. Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract onWound Healing Fereshteh. Iran Red Crescent Med J. 2017;1:19. doi:10.5812/ircmj.43788.Research
  • Eufrasia V, Pratiwi NU, Susanti R. Uji Efektivitas Penyembuhan Luka Sayat Ekstrak Rimpang Jeringau Merah (Acorus sp.) pada Tikus Putih (Rattus norvegicus) Galur Wistar. Published online 2016:1-7.
  • Fatirah N, Gama SI, Rusli R. Pengujian Toksisitas Produk Herbal Secara In Vivo. Proceeding of Mulawarman Pharmaceuticals Conferences. 2019;9:14-21. doi:10.25026/mpc.v9i1.341
  • Musa AH, Hagos AD, Dimsu GG, et al. Subchronic toxicity study of herbal tea of Moringa stenopetala (Baker f.) Cudof. and Mentha spicata L. leaves formulation in Wistar albino rats. Toxicol Rep. 2022;9:797-805. doi:10.1016/j.toxrep.2022.03.043
  • Anindita B. POTENSI NANOEMULSI EKSTRAK AKAR BURDOCK ( Arctium Lappa L.) SEBAGAI ANTIBAKTERI Staphylococcus Aureus SKRIPSI. UNIVERSITAS AL-IRSYAD CILACAP; 2022.
  • Yosri N, Alsharif SM, Xiao J, et al. Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine. Biomedicine and Pharmacotherapy. 2023;158. doi:10.1016/j.biopha.2022.114104
  • Lin SC, Chung TC, Lin CC, et al. Hepatoprotective Effects of Arctium Lappa on Carbon Tetrachloride-and Acetaminophen-Induced Liver Damage. American Journal of Chinese Medicine. 2000;28(2):163-173. www.worldscientific.com
  • Duh PD. Antioxidant Activity of Burdock (Arctium lappa Linné): Its Scavenging Effect on Free-Radical and Active Oxygen. Journal of the American Oil Chemists. 2018;75(04):422-435.
  • Ayoddhia R, Gurunanselage S, Khai M, Yap K. Biomedicine & Pharmacotherapy Arctium lappa L . root extract induces cell death via mitochondrial-mediated caspase-dependent apoptosis in Jurkat human leukemic T cells. Biomedicine & Pharmacotherapy. 2019;110(December 2018):918-929. doi:10.1016/j.biopha.2018.12.023
  • Laekeman G, Fonteyne K. Assessment report on Arctium lappa L ., radix. 2011;44(September 2010):1-26.
  • Handayani F, Sundu R, Karapa HN, Samarinda AF. UJI AKTIVITAS EKSTRAK ETANOL BIJI PINANG ( Areca catechu L .) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN ( Mus musculus ). 2016;2(2):154-160.
  • Arief H, Widodo MA, Bedah BI, et al. Peranan Stres Oksidatif Pada Proses Penyembuhan Luka Rules of Oxidative Stress in Wound Healing. 1978;2071(2):22-29.
  • Tan YJ, Ren YS, Gao L, et al. 28-Day Oral Chronic Toxicity Study of Arctigenin in Rats. Front Pharmacol. 2018;9. doi:10.3389/fphar.2018.01077
  • Gao H, Jiang XW, Yang Y, Liu WW, Xu ZH, Zhao QC. Isolation, structure elucidation and neuroprotective effects of caffeoylquinic acid derivatives from the roots of Arctium lappa L. Phytochemistry. 2020;177. doi:10.1016/j.phytochem.2020.112432
  • Anindita B. Potensi Nanoemulsi Ekstrak Akar Burdock (Arctium Lappa L.) Sebagai Antibakteri Staphylococcus Aureus. Universitas Al-Irsyad Cilacap; 22AD.
  • Jiang Y yuan, Yu J, Li Y bo, et al. Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L. Int J Biol Macromol. 2019;123:531-538. doi:10.1016/j.ijbiomac.2018.11.087
  • Agus I, Tri M, Swandari K. Metode Perbandingan Maserasi Dan Soxhletasi Ekstrak Daun Sirih Merah ( Piper crocatum Ruiz & Pav ) Terhadap Efektivitas Bakteri Staphylococcus epidermidis. 2023;4(1):64-72.
  • Widyawati R, Yunani R, Kasy F, et al. EFEKTIVITAS SALEP EKSTRAK DAUN SIRIH MERAH (Piper crocatum) TERHADAP LUKA INSISI PADA TIKUS PUTIH (Rattus norvegicus). Jurnal Vitek Bidang Kedokteran Hewan. 2021;11(2).
  • Edwards SL, Brough R, Lord CJ, et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature. 2008;451(7182):1111-1115. doi:10.1038/nature06548
  • Zebua WI, Chiuman L, Fachrial E. Histopathological evaluation of green betel leaf extract ointment on incision wounds infected with Staphylococcus aureus in wistar rats. Jurnal Teknologi Laboratorium. 2024;03(02):71-82.
  • Miari M, Taher Anan M, Bisher Zeina M. Single Valued Neutrosophic Kruskal-Wallis and Mann Whitney Tests. Neutrosophic Sets and Systems. 2022;51:948-955.
  • Hariyati LI. EFEKTIVITAS EKSTRAK ETHANOL SIRIH MERAH (Piper Crocatum) TERHADAP PENYEMBUHAN LUKA INSISI PADA TIKUS PUTIH (Rattus Norvegicus). UNIVERSITAS AIRLANGGA SURABAYA; 2017.
  • Fithriyah N. LUMATAN DAUN SIRIH MERAH (Piper crocatum) TERHADAP LAMA PENYEMBUHAN LUKA BAKAR DERAJAT II PADA KULIT KELINCI (Cavia cobaya). 2013;01(01):24-31.
  • Chen D, Li Q, Zhang H, et al. Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects. Front Pharmacol. 2022;13. doi:10.3389/fphar.2022.1025602
  • Nurhalimah H. EFEK ANTIDIARE EKSTRAK DAUN BELUNTAS ( Pluchea indica L .) TERHADAP MENCIT JANTAN YANG DIINDUKSI BAKTERI Salmonella Thypimurium Antidiarrheal Effects Beluntas Leaf Extract ( Pluchea indica L . ) against Male Mice Induced by Bacteria Salmonella typhimurium. 2015;3(3):1083-1094.
  • Pebri IG, Rinidar, Amiruddin. PENGARUH PEMBERIAN EKSTRAK DAUN BINAHONG ( Anredera cordifolia ) TERHADAP PROSES PENYEMBUHAN LUKA INSISI ( Vulnus incisivum ) PADA MENCIT ( Mus musculus ). 2017;2(November):1-11.
  • Ahmad N. In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings. Pharmaceutics. 2023;15(1). doi:10.3390/pharmaceutics15010042
  • Liu X, Wang J, Dou P, et al. The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF- ? Signaling Pathway. Oxid Med Cell Longev. 2021;2021. doi:10.1155/2021/5598980
  • Rochmah NN, Elisa I, Nugroho YE, Faizal IA, Utami DR. FORMULATION AND EVALUATION OF PHYSICAL PROPERTIES OF KATUK (Sauropus androgynus L Merr) LEAF EXTRACT TABLETS USING WET GRANULATION METHOD AS ANTIOXIDANT AND ANTIBACTERIAL. In: 3rd Borobudur International Symposium 2021. Universitas Muhammadiyah Magelang Press; 2021:22-23. doi:10.36760/jpma.v3i2.337
  • Qomariah S, Lisdiana, Christijanti W. Efektivitas Salep Ekstrak Batang Patah Tulang (Euphorbia tirucalli) Pada PEnyembuhan Luka Sayat Tikus Putih (Rattus norvegicus). 2014;3(2):79-86.
  • Fanani Z, Rosvita V, Aisah N, Pamungkas ND, Fadillah I. Formulasi Sediaan Sabun Mandi Padat Dengan Zat Aktif Ekstrak Kulit Buah Alpukat ( Persea Americana MILL ). 2021;12(2):21-26.
  • Faizal IA, Ariska Nugrahani N. Herd immunity and COVID-19 in Indonesia. Jurnal Teknologi Laboratorium. 2020;9(1):21-28. doi:10.29238/teknolabjournal.v9i1.219
  • Jannus F, Medina?o’donnell M, Neubrand VE, et al. Efficient in vitro and in vivo anti?inflammatory activity of a diamine?pegylated oleanolic acid derivative. Int J Mol Sci. 2021;22(15). doi:10.3390/ijms22158158
  • Faizal IA, Nugroho YE, Cahyani SD. BUNGA KECOMBRANG (ETLINGERA ELATIOR) SEBAGAI ANTI DEMAM BERDARAH DENGUE (DBD). In: WIJAYAKUSUMA PROSIDING SEMINAR NASIONAL. ; 2019:7.
  • Nugraha A. Rencana Asuhan Keperawatan Medikal Bedah Diagnosis Nanda -I 2015-2017 Intervensi NIC dan Hasil NOC. 2017;(May).
  • Akhmadi C, Utami W, Annisaa E. NARRATIVE REVIEW?: SENYAWA FITOKIMIA DAN AKTIVITAS. Journal of Research in Pharmacy. 2022;2(2):77-85.
  • Wu KC, Weng HK, Hsu YS, Huang PJ, Wang YK. Aqueous extract of Arctium lappa L. root (burdock) enhances chondrogenesis in human bone marrow-derived mesenchymal stem cells. BMC Complement Med Ther. 2020;20(1). doi:10.1186/s12906-020-03158-1
  • Hegazy MEF, Dawood M, Mahmoud N, et al. 2?-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action. Phytomedicine. 2021;81. doi:10.1016/j.phymed.2020.153409
  • Sharma VC, Kaushik A, Dey YN, et al. Nephroprotective potential of Anogeissus latifolia Roxb. (Dhava) against gentamicin-induced nephrotoxicity in rats. J Ethnopharmacol. 2021;273. doi:10.1016/j.jep.2021.114001
  • Okoye K, Hosseini S. Mann–Whitney U Test and Kruskal–Wallis H Test Statistics in R. In: R Programming. Springer Nature Singapore; 2024:225-246. doi:10.1007/978-981-97-3385-9_11
There is no Supplemental content for this article.

How to Cite This

Faizal, I., Jodi Irmansa, Ira Pangesti, Frinsisca Oktaviany, Aprillia Avivah Ledyana Mas’ud, Dilla Putri Oktafiani, & Silviana Dwi Yuniasari. (2024). Assessing the Therapeutic Potential of Arctium lappa L. (Burdock Root) Ethanol Extract in Wound Healing on Male Rattus norvegicus. Jurnal Teknologi Laboratorium, 13(2), 83–95. https://doi.org/10.29238/teknolabjournal.v13i2.417

Article Metrics

Download Statistics

Downloads

Download data is not yet available.

Other Statistics

Verify authenticity via CrossMark

Copyright and Permissions

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Publishing your paper with Jurnal Teknologi Laboratorium (JTL) means that the author or authors retain the copyright in the paper. JTL granted an exclusive reuse license by the author(s), but the author(s) are able to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by JTL in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.

JTL journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially.

JTL journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:

  • BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • SA:  If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

Data Availability

All data generated during this study are included in this published article [and its supplementary information files].