Abstract

Increased consumption of monosodium glutamate (MSG) is associated with various health risks, including cardiovascular and neurological disorders. MSG triggers an increase in reactive oxygen species (ROS), the end product of lipid peroxidation produced when ROS increases is Malondialdehyde (MDA), On the other hand, interleukin 10 (IL-10) reduces the inflammatory effects in infectious conditions that can cause potential tissue damage. This study investigated the effect of cinnamon bark extract (Cinnamomum burmannii) on MDA and IL-10 levels in MSG-induced Wistar rats. Experiment with Post test only control group design was conducted. The number of samples was 24 male Wistar rats divided into 4 groups. KN healthy rats, K (+) rats were only induced by MSG, P1 rats were induced by MSG and given cinnamon bark extract at a dose of 100 mg, P2 rats were induced by MSG and given cinnamon bark extract at a dose of 200 mg. The average results showed a decrease in MDA levels after 14 days of treatment, one-way ANOVA test p = 0.001 (p <0.05) showed a significant difference in MDA levels KN 2.37 mg/ml ± 0.14, K+ 2.47 mg/ml ± 0.24, P1 2.32 mg/ml ± 0.20, and P2 0.84 mg/ml ± 1.07. Meanwhile, the average IL-10 levels showed no significant difference with one-way Anova test p = 0.127 (p <0.05) in the KN group, IL-10 levels were 93.25 pg / ml ± 25.01, K (+) 112.89 pg / ml ± 43.89, P1 69.48 pg / ml ± 12.83 and P2 93.29 pg / ml ± 12.11. Administration of cinnamon bark extract can reduce MDA levels in rats induced by MSG, but has no significant effect on IL-10 levels.

There is no Figure or data content available for this article

References

• 1. Abd-Elkareem M, Soliman M, Abd El-Rahman MAM, Abou Khalil NS. The protective effect of Nigella sativa seeds against monosodium glutamate-induced hepatic dysfunction in rats. Toxicol Rep. 2022;9:147-153. doi:10.1016/j.toxrep.2022.01.014
• 2. Majewski M, Jurgo?ski A, Fotschki B, Ju?kiewicz J. The toxic effects of monosodium glutamate (MSG) – The involvement of nitric oxide, prostanoids and potassium channels in the reactivity of thoracic arteries in MSG-obese rats. Toxicol Appl Pharmacol. 2018;359:62-69. doi:10.1016/j.taap.2018.09.016
• 3. Zanfirescu A, Ungurianu A, Tsatsakis AM, et al. A Review of the Alleged Health Hazards of Monosodium Glutamate. Compr Rev Food Sci Food Saf. Published online 2019. doi:10.1111/1541-4337.12448
• 4. Hajihasani MM, Soheili V, Zirak MR, Sahebkar A, Shakeri A. Natural products as safeguards against monosodium glutamate-induced toxicity. Iran J Basic Med Sci. 2020;23(4):416-430. doi:10.22038/IJBMS.2020.43060.10123
• 5. Bera TK, Kumar Kar S, Yadav K, Mukherjee P, Yadav S, Joshi B. Effects of monosodium glutamate on human health: A systematic review. World journal of pharmaceutical sciences. 2017 Apr 26:139-44. 2017. http://www.wjpsonline.org/
• 6. Kazmi Z, Fatima I, Perveen S, Malik SS. Monosodium glutamate: Review on clinical reports. Int J Food Prop. 2017;20:1807-1815. doi:10.1080/10942912.2017.1295260
• 7. Banerjee A, Mukherjee S, Maji BK. Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview. Toxicol Rep. 2021;8:938-961. doi:10.1016/j.toxrep.2021.04.009
• 8. Kayode OT, Rotimi DE, Kayode AAA, Olaolu TD, Adeyemi OS. Monosodium glutamate (MSG)-Induced male reproductive dysfunction: A mini review. Toxics. 2020;8(1). doi:10.3390/toxics8010007
• 9. Itakura E, Huang RR, Wen DR, Paul E, Wünsch PH, Cochran AJ. IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence. Modern Pathology. 2011;24(6):801-809. doi:10.1038/modpathol.2011.5
• 10. B?aszczyk N, Rosiak A, Ka?u?na-Czapli?ska J. The potential role of cinnamon in human health. Forests. 2021;12(5):1-17. doi:10.3390/f12050648
• 11. Mohsin SN, Saleem F, Humayun A, et al. Anti-inflammatory and Analgesic Effect of 70% Cinnamon Bark (Cinnamomum burmannii Blume.) Ethanolic Extract In Vivo. Dose-Response. 2023;21(3):17-25. doi:10.1177/15593258231200527
• 12. Rahma M, Ahda Y. Pengaruh Pemberian Ekstrak Kayu Manis ( Cinnamomum Burmanii) Terhadap Jumlah Spermatazoa Pada Mencit Jantan ( Mus Musculus L.) Effect of Cinnamon Extract (Cinnamomum Burmanii) on the Number of Spermatazoa in Male Mice (Mus Musculus L.). Vol 6.; 2021.
• 13. Dewi RS, Sandhiutami NMD, Evangelia BM, Bakhtiar MT. Anti-inflammatory and Analgesic Effect of 70% Cinnamon Bark (Cinnamomum burmannii Blume.) Ethanolic Extract In Vivo. Jurnal Ilmu Kefarmasian Indonesia. 2023;21(2):273. doi:10.35814/jifi.v21i2.1374
• 14. HelmyAbdou KA, Ahmed RR, Ibrahim MA, Abdel-Gawad DRI. The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats. Environmental Science and Pollution Research. 2019;26(35):36063-36072. doi:10.1007/s11356-019-06707-5
• 15. Parisa N, Hidayat R, Maritska Z, Prananjaya BA. Antidepressant effect of cinnamon (Cinnamomum burmannii) bark extract in chronic stress-induced rats. Open Access Maced J Med Sci. 2020;8(A):273-277. doi:10.3889/oamjms.2020.3995
• 16. Wahyudi W, Chodijah C, Sumarawati T, Afrianti D. Sungkai Leaf Extract (Peronema canescens Jack) Reduces MDA Levels and Increases IL-10 Levels in MSG-Induced Wistar Rats. Poltekita?: Jurnal Ilmu Kesehatan. 2023;17(3):671-676. doi:10.33860/jik.v17i3.3015
• 17. Tawfik MS, Al-Badr N. Adverse Effects of Monosodium Glutamate on Liver and Kidney Functions in Adult Rats and Potential Protective Effect of Vitamins C and E. Food Nutr Sci. 2012;03(05):651-659. doi:10.4236/fns.2012.35089
• 18. Kazmi Z, Fatima I, Perveen S, Malik SS. Monosodium glutamate: Review on clinical reports. Int J Food Prop. 2017;20:1807-1815. doi:10.1080/10942912.2017.1295260
• 19. Lestari SA, Wardani DPK, Sudarsono TA. Lestari SA, Wardani DP, Sudarsono TA. Efek monosodium glutamat terhadap gambaran histologi hepar tikus putih (Rattus norvegicus) galur wistar. Jurnal Media Analis Kesehatan. 2021 Jun 29;12(1):56-63. Jurnal Media Analis Kesehatan. 2021;12(1):56. doi:10.32382/mak.v12i1.2000
• 20. Sachdeva M, Karan M, Singh T, Dhingra S. Oxidants and Antioxidants in Complementary and Alternative Medicine: A Review. Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery. 2014;4(1):1. doi:10.5455/spatula.20140131074751
• 21. Ain QU, Sarfraz M, Prasesti GK, Dewi TI, Kurniati NF. Confounders in identification and analysis of inflammatory biomarkers in cardiovascular diseases. Biomolecules. 2021;11(10):1-17. doi:10.3390/biom11101464
• 22. Mihai S, Codrici E, Popescu ID, et al. Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome. J Immunol Res. 2018;2018. doi:10.1155/2018/2180373
• 23. Handayani, D. R., Sari, S. M. S., Darojat, M. D. H., Permatasari, E. Y., & Djamaludin M. of Ethanol Extract of Cinnamon Bark (Cinnamomum burmanii) on the Lipid Profile and Malondialdehyde of Dyslipidemic Rats. Jurnal Profesi Medika?: Jurnal Kedokteran dan Kesehatan. 2023;17(1):24-30. doi:10.33533/jpm.v17i1.5822
• 24. Perisnawati P, Yerizel E, Alimudin T. The Effect of Cinnamon Bark Extract (Cinnamomum burmanii) on Blood Malondialdehyde (MDA) Levels in Hyperglycemia Rats. International Journal of Research and Review. 2024;11(5):1-6. doi:10.52403/ijrr.20240501
• 25. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014. doi:10.1155/2014/360438
• 26. Alyethodi RR, Sirohi AS, Karthik S, et al. Role of seminal MDA, ROS, and antioxidants in cryopreservation and their kinetics under the influence of ejaculatory abstinence in bovine semen. Cryobiology. 2021;98:187-193. doi:10.1016/j.cryobiol.2020.11.002
• 27. Acikel-Elmas M, Algilani SA, Sahin B, et al. Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters. Life. 2023;13(3). doi:10.3390/life13030822
• 28. Jia YF, Feng Q, Ge ZY, et al. Obesity impairs male fertility through long-term effects on spermatogenesis. BMC Urol. 2018;18(1). doi:10.1186/s12894-018-0360-5
• 29. Sheilaadji MU, Listiawan MY, Ervianti E. Hubungan Kadar Antioksidan Superoxide Dismutase (SOD) dengan Indeks Bakterial (IB) pada Pasien Kusta Baru Tipe Multibasiler (MB) tanpa Reaksi (Correlation of Superoxide Dismutase (SOD) Antioxidant Level with Bacterial Index (IB) in New Multibacillary (MB). Berkala Ilmu Kesehatan Kulit dan Kelamin – Periodical of Dermatology and Venereology. 2019;31(3):200-209.
• 30. Radwan RR, Mohamed HA. Nigella sativa oil modulates the therapeutic efficacy of mesenchymal stem cells against liver injury in irradiated rats. J Photochem Photobiol B. 2018;178:447-456. doi:10.1016/j.jphotobiol.2017.11.037
• 31. Abd S, Mosallam ER. Efficacy of Ascorbic Acid against Toxicity Initiated by Mono-Sodium Glutamate on Albino Mice. IOSR Journal Of Pharmacy And Biological Sciences (IOSR-JPBS. 2020;15:PP. doi:10.9790/3008-1501010108
• 32. Porro C, Cianciulli A, Panaro MA. The regulatory role of IL-10 in neurodegenerative diseases. Biomolecules. 2020;10(7):1-15. doi:10.3390/biom10071017
• 33. Gao Y, Tu D, Yang R, Chu CH, Gao HM, Hong JS. Through reducing ROS production, IL-10 suppresses caspase-1-dependent IL-1? maturation, thereby preventing chronic neuroinflammation and neurodegeneration. Int J Mol Sci. 2020;21(2):1-15. doi:10.3390/ijms21020465

There is no Supplemental content for this article.

How to Cite This

Article Metrics

Copyright and Permissions

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Publishing your paper with Jurnal Teknologi Laboratorium (JTL) means that the author or authors retain the copyright in the paper. JTL granted an exclusive reuse license by the author(s), but the author(s) are able to put the paper onto a website, distribute it to colleagues, give it to students, use it in your thesis etc, even commercially. The author(s) can reuse the figures and tables and other information contained in their paper published by JTL in future papers or work without having to ask anyone for permission, provided that the figures, tables or other information that is included in the new paper or work properly references the published paper as the source of the figures, tables or other information, and the new paper or work is not direct at private monetary gain or commercial advantage.

JTL journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. This journal is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets others remix, transform, and build upon the material for any purpose, even commercially.

JTL journal Open Access articles are distributed under this Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA). Articles can be read and shared for All purposes under the following conditions:

• BY: You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
• SA:  If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

Data Availability