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Immunology

Effect of tomato extract gel on TGF-? and IL-10 levels in UVB-exposed mice

Nur Annisa Novanda Sultan Agung Islamic University, Indonesia Correspondence nurannisanovanda1@gmail.com
,
Joko Wahyu Wibowo Faculty of Medicine Biomedical Sciences Sultan Agung Islamic University Semarang, Indonesia, Indonesia Correspondence jokowahyu01@gmail.com
,
Chodidjah Faculty of Medicine Biomedical Sciences Sultan Agung Islamic University Semarang, Indonesia, Indonesia Correspondence chodidjah@unissula.ac.id
Pages 94-103
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Abstract

Ultraviolet-B (UVB) radiation can penetrate the epidermis and can induce Deoxyribo Nucleic Acid (DNA) damage in skin cells by increasing the concentration of reactive oxygen species (ROS). Exposure to UVB radiation causes keratinocytes to form and causes inflammation to appear. Chronic inflammation is regulated by regulatory T cells, helper T cells (Th)2 that secrete tumorigenic factors including altering transforming growth factor beta (TGF-?) and interleukin-10 (IL-10).The purpose of this study was to determine the effect of tomato fruit extract gel (GEBT) on TGF-? and IL-10 levels in acute UVB-induced mice. Experiment Post Test Only Control Group Design method. The subject of this study is BALB/c mouse cells divided into 4 treatments. The treatment consisted of negative control, positive control, administration of GEBT concentration of 10%, and concentration of 20%. On the 7th day, TGF-? and IL-10 levels were checked. The data was analyzed using the Annova One Way  Test to determine the influence of each group. The Annova One Way test showed that there  was a significant difference in IL-10 levels (p<0.05), but  there was no significant difference in TGF-? levels.The administration of GEBT did not have a statistically effect on TGF-? and IL-10 levels, but clinically it can be seen from the mean that there was a difference between the treatment groups.

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How to Cite This

Nur Annisa Novanda, Joko Wahyu Wibowo, & Chodidjah. (2025). Effect of tomato extract gel on TGF-? and IL-10 levels in UVB-exposed mice . Jurnal Teknologi Laboratorium, 14(1), 94–103. https://doi.org/10.29238/teknolabjournal.v14i1.522

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