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Bacteriology

The effectiveness of nanoemulgel of pomelo peel extract (Citrus maxima) on anti-acne in Rattus norvegicus rats induced by propionibacterium acnes

Sherly Wijaya Universitas Prima Indonesia, Indonesia Correspondence sherleywijaya2310@gmail.com
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Sri Wahyuni Nasution Department of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia, Indonesia Correspondence sriwahyuni_nst88@yahoo.com
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Ali Napiah Nasution Department of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia, Indonesia Correspondence alinapiahnasution@unprimdn.ac.id
Pages 21-30
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Abstract

Acne vulgaris is a skin condition caused by chronic inflammation of the pilosebaceous follicles due to excessive sebum accumulation in the skin pores. This experimental study aimed to evaluate the effectiveness of a nanoemulgel formulated with pomelo (Citrus maxima) peel extract in treating acne lesions in Rattus norvegicus rats induced with Propionibacterium acnes. The study involved 30 male Rattus norvegicus rats aged 12–14 weeks, weighing 150–180 grams, which were divided into six groups: (1) normal group, (2) negative control (P. acnes induction and gel base), (3) positive control (P. acnes induction and Mediklin TR gel), (4) Treatment 1 (P. acnes induction and 2% nanoemulgel), (5) Treatment 2 (P. acnes induction and 3.5% nanoemulgel), and (6) Treatment 3 (P. acnes induction and 5% nanoemulgel). The nanoemulgel was applied for 10 days to evaluate the healing of acne lesions on the rats’ skin. The results showed that the nanoemulgel containing pomelo peel extract did not produce significant differences in lesion size among the treatment groups. These findings suggest that the nanoemulgel formulation used in this study did not demonstrate significant effectiveness in healing acne lesions in the P. acnes-induced rat model.

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How to Cite This

Wijaya, S., Nasution, S. W., & Nasution, A. N. (2025). The effectiveness of nanoemulgel of pomelo peel extract (Citrus maxima) on anti-acne in Rattus norvegicus rats induced by propionibacterium acnes. Jurnal Teknologi Laboratorium, 14(1), 21–30. https://doi.org/10.29238/teknolabjournal.v14i1.572

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