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Bacteriology

The effectiveness of nanoemulgel of pomelo peel extract (Citrus maxima) on anti-acne in Rattus norvegicus rats induced by propionibacterium acnes

Sherly Wijaya Universitas Prima Indonesia, Indonesia Correspondence sherleywijaya2310@gmail.com
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Sri Wahyuni Nasution Department of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia, Indonesia Correspondence sriwahyuni_nst88@yahoo.com
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Ali Napiah Nasution Department of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia, Indonesia Correspondence alinapiahnasution@unprimdn.ac.id
Pages 21-30
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Abstract

Acne vulgaris is a skin condition caused by chronic inflammation of the pilosebaceous follicles due to excessive sebum accumulation in the skin pores. This experimental study aimed to evaluate the effectiveness of a nanoemulgel formulated with pomelo (Citrus maxima) peel extract in treating acne lesions in Rattus norvegicus rats induced with Propionibacterium acnes. The study involved 30 male Rattus norvegicus rats aged 12–14 weeks, weighing 150–180 grams, which were divided into six groups: (1) normal group, (2) negative control (P. acnes induction and gel base), (3) positive control (P. acnes induction and Mediklin TR gel), (4) Treatment 1 (P. acnes induction and 2% nanoemulgel), (5) Treatment 2 (P. acnes induction and 3.5% nanoemulgel), and (6) Treatment 3 (P. acnes induction and 5% nanoemulgel). The nanoemulgel was applied for 10 days to evaluate the healing of acne lesions on the rats’ skin. The results showed that the nanoemulgel containing pomelo peel extract did not produce significant differences in lesion size among the treatment groups. These findings suggest that the nanoemulgel formulation used in this study did not demonstrate significant effectiveness in healing acne lesions in the P. acnes-induced rat model.

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References

  • 1. Wana N, Pagarra H. Efektivitas Ekstrak Pektin dari Kulit Buah Jeruk Bali (Citrus maxima) Sebagai Antimikroba. Bionature. 2019;19(2):140-151. doi:10.35580/bionature.v19i2.9732
  • 2. Elsaie ML. Hormonal treatment of acne vulgaris: An update. Clin Cosmet Investig Dermatol. 2016;9:241-248. doi:10.2147/CCID.S114830
  • 3. Sifatullah N, Zulkarnain. Jerawat (Acne vulgaris): Review Penyakit Infeksi Pada Kulit. Pros Biol Achiev Sustain Dev Goals . 2021;(November):19-23. http://journal.uin-alauddin.ac.id/index.php/psb
  • 4. Veronica E, Suyantari SAA, Swari WD, et al. Effectiveness of Antibacterial Extract of Kenop (Gomphrena Globosa) Flower Extract Against Growth of Propionibacterium Acnes Bacteria. Indones J Heal Sci. 2020;4(2):115. doi:10.24269/ijhs.v4i2.2620
  • 5. Claire KS, Lake EP. Acne and Its Variants in Special Populations. J Dermatol Nurses Assoc. 2018;10(1):S11-S14. doi:10.1097/JDN.0000000000000361
  • 6. Vasam M, Korutla S, Bohara RA. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochem Biophys Reports. 2023;36(September):101578. doi:10.1016/j.bbrep.2023.101578
  • 7. Achermann Y, Goldstein EJC, Coenye T, Shirtliffa ME. Propionibacterium acnes: From Commensal to opportunistic biofilm-associated implant pathogen. Clin Microbiol Rev. 2014;27(3):419-440. doi:10.1128/CMR.00092-13
  • 8. Luthfiyana N, Bija S, Anwar E, Laksmitawati DR, Rosalinda GL. Characteristics and activity of chitosan from mud crab shells on acne bacteria: Staphylococcus aureus, S. epidermidis and Propionibacterium acnes. Biodiversitas. 2022;23(12):6645-6651. doi:10.13057/biodiv/d231263
  • 9. Febry Autrilia R, Retno D, Ninin H. Eksplorasi Dampak Psikologis pada Remaja yang Memiliki Masalah Penampilan dengan Jerawat. J Psikol Udayana 2022. 2022;9(2):194-205. doi:10.24843/JPU/2022.v09.i02.p09
  • 10. Sibero HT, Sirajudin A, Anggraini D. Prevalensi dan Gambaran Epidemiologi Akne Vulgaris di Provinsi Lampung The Prevalence and Epidemiology of Acne Vulgaris in Lampung. J Farm Komunitas. 2019;3(2):62-68. https://e-journal.unair.ac.id/JFK/article/view/21922
  • 11. Filbert K, Wijaya S, Budi A, et al. Jambura Journal of Health Science and Research Uji Aktivitas Antibakteri Ekstrak Kulit Jeruk Bali (Citrus Maxima Pericarpium) Terhadap Pseudomonas Aeruginosa Dan Enterococcus Faecalis Antibacterial Activity Test of Pomelo Peel Extract (Citrux Maxima Peric. Published online 2022. https://ejurnal.ung.ac.id/index.php/jjhsr/index
  • 12. Barqy N, Matematika F, Alam P, Udayana U. REVIEW?: SENYAWA PENYUSUN MINYAK ATSIRI KULIT JERUK BALI ( Citrus maxima ) DAN AKTIVITAS FARMAKOLOGINYA REVIEW?: CHEMICAL CONSTITUENT ESSENTIAL OIL OF POMELO PEEL ( Citrus maxima ) AND PHARMACOLOGICAL ACTIVITY Alamat Korespondensi?: PENDAHULUAN Citrus max. 2021;5(2):89-98.
  • 13. PARIURY JA, JUAN PAUL CHRISTIAN HERMAN, TIFFANY REBECCA, ELVINA VERONICA, I GUSTI KAMASAN NYOMAN ARIJANA. Potensi Kulit Jeruk Bali (Citrus Maxima Merr) Sebagai Antibakteri Propionibacterium acne Penyebab Jerawat. Hang Tuah Med J. 2021;19(1):119-131. doi:10.30649/htmj.v19i1.65
  • 14. Xiang N, Zhao Y, Zhang B, Gu Q, Chen W, Guo X. Volatiles Accumulation during Young Pomelo (Citrus maxima (Burm.) Merr.) Fruits Development. Int J Mol Sci. 2022;23(10). doi:10.3390/ijms23105665
  • 15. Wijayanti T, Narimo N. AKTIVITAS TEH KULIT BUAH JERUK BALI (Citrus maxima Merr) SEBAGAI PENURUN KADAR KOLESTEROL TOTAL UNTUK PENCEGAHAN PREEKLAMPSIA SELAMA KEHAMILAN. Din Kesehat J Kebidanan Dan Keperawatan. 2020;11(1):353-361. doi:10.33859/dksm.v11i1.620
  • 16. Suryanita S, Aliyah A, Djabir YY, Wahyudin E, Rahman L, Yulianty R. IDENTIFIKASI SENYAWA KIMIA DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL KULIT JERUK BALI (Citrus maxima Merr.). Maj Farm dan Farmakol. 2019;23(1):16-20. doi:10.20956/mff.v23i1.6461
  • 17. Imanto T, Prasetiawan R, Wikantyasning ER. Formulasi dan Karakterisasi Sediaan Nanoemulgel Serbuk Lidah Buaya (Aloe Vera L.). Pharmacon J Farm Indones. 2019;16(1):28-37. doi:10.23917/pharmacon.v16i1.8114
  • 18. 18. Tran NYT, Le TD, Dao PT, Bach GL, Huynh PX, Tran QN. Evaluation of different extraction methods on the polyphenols yield, flavonoids yield, and antioxidant activity of the pomelo flavedo extract from Da Xanh (Citrus maxima [burm] merr.) variety. Food Sci Technol. 2022;42:1-9. doi:10.1590/fst.97021
  • 19. Syam AA, Marini M. OPTIMASI FORMULASI SEDIAAN HANBODY LOTION DARI EKSTRAK KULIT JERUK BALI ( Citrus maxima (Burm.) Merr. ) SEBAGAI ANTIOKSIDAN. J Farmaku (Farmasi Muhammadiyah Kuningan). 2020;5(2):32-38. doi:10.55093/jurnalfarmaku.v5i2.135
  • 20. Diedrich C, Zittlau IC, Khalil NM, et al. Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release. Pharmaceutics. 2023;15(6). doi:10.3390/pharmaceutics15061592
  • 21. Thomas NA, Tungadi R, Hiola F, S. Latif M. Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera). Indones J Pharm Educ. 2023;3(2):316-324. doi:10.37311/ijpe.v3i2.18050
  • 22. Indalifiany A, Malaka MH, Sahidin, Fristiohady A, Andriani R. Formulasi Dan Uji Stabilitas Fisik Nanoemulgel Formulation And Physical Stability Test Of Nanoemulgel Containing Petrosia Sp . J Farm Sains dan Prakt. 2021;7(3):321-331.
  • 23. Rizki SA, Latief M, Rahman H. Uji Aktivitas Antibakteri Ekstrak N-Heksan, Etil Asetat Dan Etanol Daun Durian (Durio zibethinus Linn.) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus epidermidis. J Mhs Farm. Published online 2021:442-457.
  • 24. Amalyuri AG, Reveny J, Dalimunthe A. Antibacterial Potential Of Ethanol Extract Of Tamarind Seed Bark (Tamarindus indica L.) And Formulation Of Anti-Acne Nanogel. Int J Sci Technol Manag. 2022;3(3):598-604. doi:10.46729/ijstm.v3i3.522
  • 25. Lal DK, Kumar B, Saeedan AS, Ansari MN. An Overview of Nanoemulgels for Bioavailability Enhancement in Inflammatory Conditions via Topical Delivery. Pharmaceutics. 2023;15(4). doi:10.3390/pharmaceutics15041187
  • 26. Eid AM, Naseef H, Jaradat N, Ghanim L, Moqadeh R, Yaseen M. Antibacterial and Anti-Acne Activity of Benzoyl Peroxide Nanoparticles Incorporated in Lemongrass Oil Nanoemulgel. Gels. 2023;9(3):1-12. doi:10.3390/gels9030186
  • 27. Sari R, Reveny J, Salim E. Formulation and effectiveness test of Tekelan leaf ethanol extract nanogel preparations against Propionibacterium acnes. Int J Basic Clin Pharmacol. 2024;13(5):580-586. doi:10.18203/2319-2003.ijbcp20241943
  • 28. Kotb EA, El-Shiekh RA, Hassan M, Abd-Elsalam WH, El Tanbouly N, El Senousy AS. Potential anti-acne loaded nanogel formulations of Origanum majorana L. and Chrysanthemum morifolium Ramat. essential oils. Appl Biol Chem. 2024;67(1). doi:10.1186/s13765-024-00859-w
  • 29. Bashir M, Ahmad J, Asif M, et al. Nanoemulgel, an innovative carrier for diflunisal topical delivery with profound anti-inflammatory effect: In vitro and in vivo evaluation. Int J Nanomedicine. 2021;16:1457-1472. doi:10.2147/IJN.S294653
  • 30. Ullah N, Amin A, Farid A, et al. Development and Evaluation of Essential Oil-Based Nanoemulgel Formulation for the Treatment of Oral Bacterial Infections. Gels. 2023;9(3). doi:10.3390/gels9030252
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How to Cite This

Wijaya, S., Nasution, S. W., & Nasution, A. N. (2025). The effectiveness of nanoemulgel of pomelo peel extract (Citrus maxima) on anti-acne in Rattus norvegicus rats induced by propionibacterium acnes. Jurnal Teknologi Laboratorium, 14(1), 21–30. https://doi.org/10.29238/teknolabjournal.v14i1.572

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